P-Value — What It Means in Clinical Trials
Plain English Definition
A p-value is a number that tells you how likely it is that the trial's results happened by chance. A small p-value (typically less than 0.05) means the results are probably real, not random. A p-value of 0.05 means there is only a 5% probability the results are due to chance. The smaller the p-value, the stronger the evidence.
Why It Matters
You will see p-values in trial results. A p-value less than 0.05 is generally considered statistically significant. But remember — a p-value tells you about the probability of chance, not about how big or important the treatment effect is.
Example
A trial result might say: "Overall response rate: 45% vs 20% (p<0.001)." The p<0.001 means there is less than a 0.1% chance this difference is just luck.
Need help understanding eligibility criteria?
How to Read Eligibility Criteria →